It is an old trick of the trade where a physician may prescribe vaginal premarin cream to treat recurrent nosebleeds . The premarin (estrogen) cream (just as it does when placed vaginally) causes the nasal mucosa lining to thicken thereby "burying" the superficial blood vessels that are often the culprits for recurrent nosebleeds. Application is by rubbing the cream 2-3X per day to the anterior wall of the nasal septum ( Kiesselbach's plexus ) where 90% of nosebleed sources ar…